A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis
Joint Authors
Hwang, Daw-Yang
Wu, Mei-Shin
Chang, Che-Mai
Yen, Jeng-Hsien
Chen, Ben-Kuen
Liao, Hsien-Tzung
Wu, Man-Tzu Marcie
Hsu, Yu-Wen
Lee, Chih-Hung
Chang, Wei Chiao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors.
ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases.
To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study.
Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping.
An SNP, rs7135617, showed a significant correlation with the risk of RA.
Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.
American Psychological Association (APA)
Yen, Jeng-Hsien& Chang, Che-Mai& Hsu, Yu-Wen& Lee, Chih-Hung& Wu, Mei-Shin& Hwang, Daw-Yang…[et al.]. 2014. A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043839
Modern Language Association (MLA)
Yen, Jeng-Hsien…[et al.]. A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis. Mediators of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043839
American Medical Association (AMA)
Yen, Jeng-Hsien& Chang, Che-Mai& Hsu, Yu-Wen& Lee, Chih-Hung& Wu, Mei-Shin& Hwang, Daw-Yang…[et al.]. A Polymorphism of ORAI1 rs7135617, Is Associated with Susceptibility to Rheumatoid Arthritis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043839
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043839