![](/images/graphics-bg.png)
Inhibition of Macrophage Functions by the C-Terminus of Murine S100A9 Is Dependent on B-1 Cells
Joint Authors
Mariano, Mario
Pagano, Rosana Lima
Moraes, Natassja Foizer
De Lorenzo, Beatriz Helena
Coccuzzo Sampaio, Sandra
Giorgi, Renata
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The protein S100A9 plays a key role in the control of inflammatory response.
The C-terminus of the murine S100A9 protein (mS100A9p) downregulates the spreading and phagocytic activity of adherent peritoneal cells.
Murine peritoneal cells are constituted by macrophages and B-1 cells, and the latter exert an inhibitory effect on macrophage functions by secreting interleukin- (IL-) 10.
Here, we investigated the influence of B-1 cells on the inhibitory effect evoked by mS100A9p on macrophages.
mS100A9p did not alter spreading and phagocytosis either by peritoneal macrophages obtained from mice deprived of B-1 cells or by bone marrow-derived macrophages (BMDMϕ).
Nevertheless, when BMDMϕ were cocultivated by direct or indirect contact with B-1 cells treated with mS100A9p, the phagocytosis by BMDMϕ was decreased, showing that the effect of mS100A9p on macrophages was modulated by B-1 cells and/or their secretory compounds.
Furthermore, the inhibitory action of mS100A9p on phagocytosis by adherent peritoneal cells was abolished in cells obtained from IL-10 knockout mice.
Taken together, the results show that mS100A9p has no direct inhibitory effect on macrophages; however, mS100A9p modulates B-1 cells, which in turn downregulates macrophages, at least in part, via IL-10.
These data contribute to the characterization of S100A9 functions involving B-1 cells in the regulation of the inflammatory process.
American Psychological Association (APA)
Pagano, Rosana Lima& Moraes, Natassja Foizer& De Lorenzo, Beatriz Helena& Coccuzzo Sampaio, Sandra& Mariano, Mario& Giorgi, Renata. 2014. Inhibition of Macrophage Functions by the C-Terminus of Murine S100A9 Is Dependent on B-1 Cells. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043841
Modern Language Association (MLA)
Pagano, Rosana Lima…[et al.]. Inhibition of Macrophage Functions by the C-Terminus of Murine S100A9 Is Dependent on B-1 Cells. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043841
American Medical Association (AMA)
Pagano, Rosana Lima& Moraes, Natassja Foizer& De Lorenzo, Beatriz Helena& Coccuzzo Sampaio, Sandra& Mariano, Mario& Giorgi, Renata. Inhibition of Macrophage Functions by the C-Terminus of Murine S100A9 Is Dependent on B-1 Cells. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043841
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043841