Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice
Joint Authors
Martins, Amanda Roque
Neto, José César Rosa
Souza, Gabriel I. H.
Masi, Laureane Nunes
Santamarina, Aline Boveto
Silveira, Loreana S.
Crisma, Amanda R.
Davanso, Mariana R.
Moreira, Renata G.
Sousa, Luis Gustavo O. de
de Lima Júnior, Edson Alves
Hirabara, Sandro Massao
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and inflammation.
Macadamia oil administration has been shown to improve lipid profile in humans.
We evaluated the effect of macadamia oil supplementation on insulin sensitivity, inflammation, lipid profile, and adipocyte size in high-fat diet (HF) induced obesity in mice.
C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD supplemented with macadamia oil by gavage at 2 g/Kg of body weight, three times per week, for 12 weeks (CD + MO), and (d) HF diet supplemented with macadamia oil (HF + MO).
CD and HF mice were supplemented with water.
HF mice showed hypercholesterolemia and decreased insulin sensitivity as also previously shown.
HF induced inflammation in adipose tissue and peritoneal macrophages, as well as adipocyte hypertrophy.
Macadamia oil supplementation attenuated hypertrophy of adipocytes and inflammation in the adipose tissue and macrophages.
American Psychological Association (APA)
de Lima Júnior, Edson Alves& Silveira, Loreana S.& Masi, Laureane Nunes& Crisma, Amanda R.& Davanso, Mariana R.& Souza, Gabriel I. H.…[et al.]. 2014. Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043859
Modern Language Association (MLA)
de Lima Júnior, Edson Alves…[et al.]. Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043859
American Medical Association (AMA)
de Lima Júnior, Edson Alves& Silveira, Loreana S.& Masi, Laureane Nunes& Crisma, Amanda R.& Davanso, Mariana R.& Souza, Gabriel I. H.…[et al.]. Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043859
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043859