The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice
Joint Authors
Cunha, Fernando Queiroz
Nomizo, Auro
Canavaci, Adriana M. C.
Martins, Vicente P.
Morais, Fabiana R.
de Sousa, Érika V. G.
Trindade, Bruno C.
Rossi, Marcos A.
Aronoff, David M.
Artério Sorgi, Carlos
Faccioli, Lúcia Helena
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In the present work we examine the contribution of 5-lipoxygenase- (5-LO-) derived lipid mediators to immune responses during the acute phase of Trypanosoma cruzi infection in 5-LO gene knockout (5-LO−/−) mice and wild-type (WT) mice.
Compared with WT mice, the 5-LO−/− mice developed less parasitemia/tissue parasitism, less inflammatory cell infiltrates, and a lower mortality.
This resistance of 5-LO−/− mice correlated with several differences in the immune response to infection, including reduced PGE2 synthesis; sustained capacity of splenocytes to produce high levels of interleukin (IL)-12 early in the infection; enhanced splenocyte production of IL-1β, IL-6, and IFN-γ; rapid T-cell polarization to secrete high quantities of IFN-γ and low quantities of IL-10; and greater numbers of CD8+ C D 4 4 h i g h C D 62 L l o w memory effector T cells at the end of the acute phase of infection.
The high mortality in WT mice was associated with increased production of LTB4/LTC4, T cell bias to produce IFN-γ, high levels of serum nitrite, and marked protein extravasation into the peritoneal cavity, although survival was improved by treatment with a cys-LT receptor 1 antagonist.
These data also provide evidence that 5-LO-derived mediators negatively affect host survival during the acute phase of T.
cruzi infection.
American Psychological Association (APA)
Canavaci, Adriana M. C.& Artério Sorgi, Carlos& Martins, Vicente P.& Morais, Fabiana R.& de Sousa, Érika V. G.& Trindade, Bruno C.…[et al.]. 2014. The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1043867
Modern Language Association (MLA)
Canavaci, Adriana M. C.…[et al.]. The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice. Mediators of Inflammation No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1043867
American Medical Association (AMA)
Canavaci, Adriana M. C.& Artério Sorgi, Carlos& Martins, Vicente P.& Morais, Fabiana R.& de Sousa, Érika V. G.& Trindade, Bruno C.…[et al.]. The Acute Phase of Trypanosoma cruzi Infection Is Attenuated in 5-Lipoxygenase-Deficient Mice. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1043867
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043867