Role of Inflammatory Mediators in the Pathogenesis of Epilepsy
Joint Authors
Shimada, Tadayuki
Takemiya, Takako
Sugiura, Hiroko
Yamagata, Kanato
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Epilepsy is one of the most common chronic brain disorders worldwide, affecting 1% of people across different ages and backgrounds.
Epilepsy is defined as the sporadic occurrence of spontaneous recurrent seizures.
Accumulating preclinical and clinical evidence suggest that there is a positive feedback cycle between epileptogenesis and brain inflammation.
Epileptic seizures increase key inflammatory mediators, which in turn cause secondary damage to the brain and increase the likelihood of recurrent seizures.
Cytokines and prostaglandins are well-known inflammatory mediators in the brain, and their biosynthesis is enhanced following seizures.
Such inflammatory mediators could be therapeutic targets for the development of new antiepileptic drugs.
In this review, we discuss the roles of inflammatory mediators in epileptogenesis.
American Psychological Association (APA)
Shimada, Tadayuki& Takemiya, Takako& Sugiura, Hiroko& Yamagata, Kanato. 2014. Role of Inflammatory Mediators in the Pathogenesis of Epilepsy. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043873
Modern Language Association (MLA)
Shimada, Tadayuki…[et al.]. Role of Inflammatory Mediators in the Pathogenesis of Epilepsy. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043873
American Medical Association (AMA)
Shimada, Tadayuki& Takemiya, Takako& Sugiura, Hiroko& Yamagata, Kanato. Role of Inflammatory Mediators in the Pathogenesis of Epilepsy. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043873