Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis
Joint Authors
Teixeira-Carvalho, Andréa
Machado, Anderson Silva
Carneiro, Ana Carolina Aguiar Vasconcelos
Béla, Samantha Ribeiro
Andrade, Gláucia Manzan Queiroz
Vasconcelos-Santos, Daniel Vitor
Januário, José Nélio
Coelho-dos-Reis, Jordana G.
Ferro, Eloisa Amália Vieira
Vitor, Ricardo Wagner Almeida
Martins-Filho, Olindo Assis
—UFMG-CTBG, UFMG Congenital Toxoplasmosis Brazilian Group
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Toxoplasma gondii is the main infectious cause of human posterior retinochoroiditis, the most frequent clinical manifestation of congenital toxoplasmosis.
This investigation was performed after neonatal screening to identify biomarkers of immunity associated with immunopathological features of the disease by flow cytometry.
The study included infected infants without NRL and with retinochoroidal lesions (ARL, ACRL, and CRL) as well as noninfected individuals (NI).
Our data demonstrated that leukocytosis, with increased monocytes and lymphocytes, was a relevant hematological biomarker of ARL.
Immunophenotypic analysis also revealed expansion of CD14+CD16+HLA-DRhigh monocytes and CD56dim cytotoxic NK-cells in ARL.
Moreover, augmented TCRγδ+ and CD8+ T-cell counts were apparently good biomarkers of morbidity.
Biomarker network analysis revealed that complex and intricated networks underscored the negative correlation of monocytes with NK- and B-cells in NRL.
The remarkable lack of connections involving B-cells and a relevant shift of NK-cell connections from B-cells toward T-cells observed in ARL were outstanding.
A tightly connected biomarker network was observed in CRL, with relevant connections of NK- and CD8+ T-cells with a broad range of cell subsets.
Our findings add novel elements to the current knowledge on the innate and adaptive immune responses in congenital toxoplasmosis.
American Psychological Association (APA)
Machado, Anderson Silva& Carneiro, Ana Carolina Aguiar Vasconcelos& Béla, Samantha Ribeiro& Andrade, Gláucia Manzan Queiroz& Vasconcelos-Santos, Daniel Vitor& Januário, José Nélio…[et al.]. 2014. Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043882
Modern Language Association (MLA)
Machado, Anderson Silva…[et al.]. Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043882
American Medical Association (AMA)
Machado, Anderson Silva& Carneiro, Ana Carolina Aguiar Vasconcelos& Béla, Samantha Ribeiro& Andrade, Gláucia Manzan Queiroz& Vasconcelos-Santos, Daniel Vitor& Januário, José Nélio…[et al.]. Biomarker Analysis Revealed Distinct Profiles of Innate and Adaptive Immunity in Infants with Ocular Lesions of Congenital Toxoplasmosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043882
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043882