Chagas Disease: Still Many Unsolved Issues
Joint Authors
Lima, Regina
da Silva, Henrique B.
Marinho, Claudio R. F.
Alvarez, José M.
Epiphanio, Sabrina
Fonseca, Raissa
Sardinha, Luiz Roberto
Bortoluci, Karina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described.
However, the main questions on the physiopathology of Chagas disease remain unanswered: “Why does the host immune system fail to provide sterile immunity?” and “Why do only a proportion of infected individuals develop chronic pathology?” In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease.
Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T.
cruzi contributes to parasite persistence in the heart and the development of chronic pathology.
American Psychological Association (APA)
Alvarez, José M.& Fonseca, Raissa& da Silva, Henrique B.& Marinho, Claudio R. F.& Bortoluci, Karina& Sardinha, Luiz Roberto…[et al.]. 2014. Chagas Disease: Still Many Unsolved Issues. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043890
Modern Language Association (MLA)
Alvarez, José M.…[et al.]. Chagas Disease: Still Many Unsolved Issues. Mediators of Inflammation No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1043890
American Medical Association (AMA)
Alvarez, José M.& Fonseca, Raissa& da Silva, Henrique B.& Marinho, Claudio R. F.& Bortoluci, Karina& Sardinha, Luiz Roberto…[et al.]. Chagas Disease: Still Many Unsolved Issues. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1043890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043890