CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases
Joint Authors
Rodriguez-Ramirez, Heidi G.
Salinas-Carmona, Mario C.
Barboza-Quintana, Oralia
Melo-de la Garza, Americo
Ceceñas-Falcon, Luis Angel
Rangel-Martinez, Lilia M.
Rosas-Taraco, Adrian G.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In 2009, a new influenza A (H1N1) virus affected many persons around the world.
There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1)pdm09 and seasonal influenza virus.
We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1)pdm09.
Cytokines (inflammatory and anti-inflammatory) and cellular markers (macrophages and lymphocytes subpopulation markers) were analyzed in lung tissue from both influenza A (H1N1)pdm09 and seasonal influenza virus.
High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1)pdm09 and seasonal cases when compared with healthy lung tissue (P<0.05).
Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1)pdm09 and seasonal influenza virus (P<0.05).
Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung) were found in influenza A (H1N1)pdm09 when compared with seasonal influenza virus (P<0.05), and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1)pdm09 (P<0.05).
In conclusion, CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases.
American Psychological Association (APA)
Rodriguez-Ramirez, Heidi G.& Salinas-Carmona, Mario C.& Barboza-Quintana, Oralia& Melo-de la Garza, Americo& Ceceñas-Falcon, Luis Angel& Rangel-Martinez, Lilia M.…[et al.]. 2014. CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043896
Modern Language Association (MLA)
Rodriguez-Ramirez, Heidi G.…[et al.]. CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043896
American Medical Association (AMA)
Rodriguez-Ramirez, Heidi G.& Salinas-Carmona, Mario C.& Barboza-Quintana, Oralia& Melo-de la Garza, Americo& Ceceñas-Falcon, Luis Angel& Rangel-Martinez, Lilia M.…[et al.]. CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043896