Mediators of Mast Cells in Bullous Pemphigoid and Dermatitis Herpetiformis
Joint Authors
Stasikowska-Kanicka, Olga
Waszczykowska, Elzbieta
Kulczycka-Siennicka, Lilianna
Wozniacka, Anna
Marian, Danilewicz
Zebrowska, Agnieszka
Wagrowska-Danilewicz, Malgorzata
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are skin diseases associated with inflammation.
However, few findings exist concerning the role of mast cells in autoimmune blistering disease.
Skin biopsies were taken from 27 BP and 14 DH patients, as well as 20 healthy individuals.
Immunohistochemistry was used to identify the localization and mast cell expression of TNFα and MMP9 in skin lesions and perilesional skin.
The serum concentrations of TNFα, MMP9, chymase, tryptase, PAF, and IL-4 were measured by immunoassay.
TNFα and MMP9 expression in the epidermis and in inflammatory influxed cells in the dermis was detected in skin biopsies from patients.
Although these mediators were found to be expressed in the perilesional skin of all patients, the level was much lower than that in lesional skin.
Increased serum PAF levels were observed in BP patients.
Mast cells may play an essential role in activating inflammation, which ultimately contributes to the tissue damage observed in BP and DH.
Our findings suggest that differences in the pattern of cytokine expression directly contribute to variations in cellular infiltration in DH and BP.
American Psychological Association (APA)
Zebrowska, Agnieszka& Wagrowska-Danilewicz, Malgorzata& Marian, Danilewicz& Stasikowska-Kanicka, Olga& Kulczycka-Siennicka, Lilianna& Wozniacka, Anna…[et al.]. 2014. Mediators of Mast Cells in Bullous Pemphigoid and Dermatitis Herpetiformis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043916
Modern Language Association (MLA)
Zebrowska, Agnieszka…[et al.]. Mediators of Mast Cells in Bullous Pemphigoid and Dermatitis Herpetiformis. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043916
American Medical Association (AMA)
Zebrowska, Agnieszka& Wagrowska-Danilewicz, Malgorzata& Marian, Danilewicz& Stasikowska-Kanicka, Olga& Kulczycka-Siennicka, Lilianna& Wozniacka, Anna…[et al.]. Mediators of Mast Cells in Bullous Pemphigoid and Dermatitis Herpetiformis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043916
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043916