Untangling the Web of Systemic Autoinflammatory Diseases
Joint Authors
Vitale, Antonio
Cantarini, Luca
Lopalco, Giuseppe
De Clemente, Caterina
Molinaro, Francesco
Messina, Mario
Laghi-Pasini, Franco
Lapadula, Giovanni
Atteno, Mariangela
Rigante, Donato
Costa, Luisa
Caso, Francesco
Iannone, Florenzo
Lucherini, Orso Maria
Galeazzi, Mauro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The innate immune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1β and tumor necrosis factor-α, in which autoreactive T-lymphocytes and autoantibodies are indeed absent.
A widely deranged innate immunity leads to overactivity of proinflammatory cytokines and subsequent multisite inflammatory symptoms depicting various conditions, such as hereditary periodic fevers, granulomatous disorders, and pyogenic diseases, collectively described in this review.
Further research should enhance our understanding of the genetics behind SAIDs, unearth triggers of inflammatory attacks, and result in improvement for their diagnosis and treatment.
American Psychological Association (APA)
Rigante, Donato& Lopalco, Giuseppe& Vitale, Antonio& Lucherini, Orso Maria& Caso, Francesco& De Clemente, Caterina…[et al.]. 2014. Untangling the Web of Systemic Autoinflammatory Diseases. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043919
Modern Language Association (MLA)
Rigante, Donato…[et al.]. Untangling the Web of Systemic Autoinflammatory Diseases. Mediators of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043919
American Medical Association (AMA)
Rigante, Donato& Lopalco, Giuseppe& Vitale, Antonio& Lucherini, Orso Maria& Caso, Francesco& De Clemente, Caterina…[et al.]. Untangling the Web of Systemic Autoinflammatory Diseases. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043919