Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response
Joint Authors
de Franco, Marcelo
Vorraro, Francisca
Cabrera, Wafa H. K.
Ribeiro, Orlando G.
Jensen, José Ricardo
Ibañez, Olga M.
Starobinas, Nancy
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-12
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Trypanosoma cruzi infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high ( H I I I ) or low ( L I I I ) antibody (Ab) responses to complex antigens.
Resistance was associated with gender (females) and strain—the high responder lines AIRmax and H I I I were resistant.
The higher resistance of H I I I as compared to L I I I mice extended to higher infective doses and was correlated with enhanced production of IFN- γ and nitric oxide production by peritoneal and lymph node cells, in H I I I males and females.
We also analyzed the involvement of previously mapped Ab and T.
cruzi response QTL with the survival of Selection III mice to T.
cruzi infections in a segregating backcross [F1( H I I I × L I I I ) × L I I I ] population.
An Ab production QTL marker mapping to mouse chromosome 1 (34.8 cM) significantly cosegregated with survival after acute T.
cruzi infections, indicating that this region also harbors genes whose alleles modulate resistance to acute T.
cruzi infection.
American Psychological Association (APA)
Vorraro, Francisca& Cabrera, Wafa H. K.& Ribeiro, Orlando G.& Jensen, José Ricardo& de Franco, Marcelo& Ibañez, Olga M.…[et al.]. 2014. Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043921
Modern Language Association (MLA)
Vorraro, Francisca…[et al.]. Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response. Mediators of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043921
American Medical Association (AMA)
Vorraro, Francisca& Cabrera, Wafa H. K.& Ribeiro, Orlando G.& Jensen, José Ricardo& de Franco, Marcelo& Ibañez, Olga M.…[et al.]. Trypanosoma cruzi Infection in Genetically Selected Mouse Lines: Genetic Linkage with Quantitative Trait Locus Controlling Antibody Response. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043921