Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17Treg Balance and Osteoclastogenesis
Joint Authors
Kim, Kyoung Woon
Lee, Jennifer
Kim, Eun-Kyung
Cho, Mi-La
Son, Hye-Jin
Lee, Seon-Yeong
Park, Min-Jung
Park, Sung-Hwan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Metformin is widely used to suppress certain functions of the cells found in diseases including diabetes and obesity.
In this study, the effects of metformin on downregulating IL-17-producing T (Th17) cells, activating and upregulating regulatory T (Treg) cells, suppressing osteoclastogenesis, and clinically scoring collagen-induced arthritis (CIA) were investigated.
To evaluate the effect of metformin on CIA, mice were orally fed with either metformin or saline as control three times a week for nine weeks.
Histological analysis of the joints was performed using immunohistochemistry and Th17 cells and Treg cells of the spleen tissue were examined by confocal microscopy staining.
Metformin mitigated the severity of CIA, reduced serum immunoglobulin concentrations, and reciprocally regulated Th17/Treg axis.
Also, metformin treatment of normal cells cultured in Th17 conditions decreased the number of Th17 cells and increased the number of Treg cells.
Metformin decreased gene expression and osteoclastogenic activity in CIA and normal mice.
These results indicate that metformin had immunomodulatory actions influencing anti-inflammatory action on CIA through the inhibition of Th17 cell differentiation and the upregulation of Treg cell differentiation along with the suppression of osteoclast differentiation.
Our results suggest that metformin may be a potential therapeutic for rheumatoid arthritis.
American Psychological Association (APA)
Son, Hye-Jin& Lee, Jennifer& Lee, Seon-Yeong& Kim, Eun-Kyung& Park, Min-Jung& Kim, Kyoung Woon…[et al.]. 2014. Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17Treg Balance and Osteoclastogenesis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043937
Modern Language Association (MLA)
Son, Hye-Jin…[et al.]. Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17Treg Balance and Osteoclastogenesis. Mediators of Inflammation No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1043937
American Medical Association (AMA)
Son, Hye-Jin& Lee, Jennifer& Lee, Seon-Yeong& Kim, Eun-Kyung& Park, Min-Jung& Kim, Kyoung Woon…[et al.]. Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17Treg Balance and Osteoclastogenesis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1043937
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043937