Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis
Joint Authors
Miric, Dijana
Grbic, Rade
Popovic, Ljiljana
Nestorovic, Vojkan
Vasic, Aleksandar
Kisic, Bojana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress.
Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability.
The physiological functions of vitamin C largely depend on its redox status.
We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM).
Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower ( P < 0.05 , resp.).
On the other side, total vitamin C levels in patients and controls were similar ( P > 0.05 ) , thereby suggesting a relative rather than absolute vitamin C deficiency in OM.
During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations.
Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM.
In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.
American Psychological Association (APA)
Grbic, Rade& Miric, Dijana& Kisic, Bojana& Popovic, Ljiljana& Nestorovic, Vojkan& Vasic, Aleksandar. 2014. Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043943
Modern Language Association (MLA)
Grbic, Rade…[et al.]. Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043943
American Medical Association (AMA)
Grbic, Rade& Miric, Dijana& Kisic, Bojana& Popovic, Ljiljana& Nestorovic, Vojkan& Vasic, Aleksandar. Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043943
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043943