Obesity, Inflammation, and Lung Injury (OILI): The Good
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-11
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Obesity becomes pandemic, predisposing these individuals to great risk for lung injury.
In this review, we focused on the anti-inflammatories and addressed the following aspects: adipocytokines and obesity, inflammation and other mechanisms, adipocytokines and lung injury in obesity bridged by inflammation, and potential therapeutic targets.
To sum up, the majority of evidence supported that adiponectin, omentin, and secreted frizzled-related protein 5 (SFRP5) were reduced significantly in obesity, which is associated with increased inflammation, indicated by increase of TNFα and IL-6, through activation of toll-like receptor (TLR4) and nuclear factor light chain κB (NF-κB) signaling pathways.
Administration of these adipocytokines promotes weight loss and reduces inflammation.
Zinc-α2-glycoprotein (ZAG), vaspin, IL-10, interleukin-1 receptor antagonist (IL-1RA), transforming growth factor β (TGF-β1), and growth differentiation factor 15 (GDF15) are also regarded as anti-inflammatories.
There were controversial reports.
Furthermore, there is a huge lack of studies for obesity related lung injury.
The effects of adiponectin on lung transplantation, asthma, chronic obstructive pulmonary diseases (COPD), and pneumonia were anti-inflammatory and protective in lung injury.
Administration of IL-10 agonist reduces mortality of acute lung injury in rabbits with acute necrotizing pancreatitis, possibly through inhibiting proinflammation and strengthening host immunity.
Very limited information is available for other adipocytokines.
American Psychological Association (APA)
Wang, Cheryl. 2014. Obesity, Inflammation, and Lung Injury (OILI): The Good. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043946
Modern Language Association (MLA)
Wang, Cheryl. Obesity, Inflammation, and Lung Injury (OILI): The Good. Mediators of Inflammation No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1043946
American Medical Association (AMA)
Wang, Cheryl. Obesity, Inflammation, and Lung Injury (OILI): The Good. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1043946
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043946