Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits
Joint Authors
Fan, Jianglin
Yu, Qi
Liu, Enqi
Graham, Mark J.
Crooke, Rosanne M.
Liu, Zhengcao
Ning, Bo
Yang, Xianghong
Dong, Sijun
Waqar, Ahmed Bilal
Shiomi, Masashi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis of atherosclerosis is still under debate.
Many controversial and contradictory results using transgenic mice and rabbits have been published but it is also unclear whether CRP lowering can be used for the treatment of atherosclerosis.
In the current study, we examined the effects of the rabbit CRP antisense oligonucleotides (ASO) on the development of atherosclerosis in WHHL rabbits.
CRP ASO treatment led to a significant reduction of plasma CRP levels; however, both aortic and coronary atherosclerotic lesions were not significantly changed compared to those of control WHHL rabbits.
These results suggest that inhibition of plasma CRP does not affect the development of atherosclerosis in WHHL rabbits.
American Psychological Association (APA)
Yu, Qi& Liu, Zhengcao& Waqar, Ahmed Bilal& Ning, Bo& Yang, Xianghong& Shiomi, Masashi…[et al.]. 2014. Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043948
Modern Language Association (MLA)
Yu, Qi…[et al.]. Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043948
American Medical Association (AMA)
Yu, Qi& Liu, Zhengcao& Waqar, Ahmed Bilal& Ning, Bo& Yang, Xianghong& Shiomi, Masashi…[et al.]. Effects of Antisense Oligonucleotides against C-Reactive Protein on the Development of Atherosclerosis in WHHL Rabbits. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043948