Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome
Joint Authors
Durand, Thierry
Maffei, Silvia
Cannarile, Pierpaolo
Pecorelli, Alessandra
Lunghetti, Stefano
Ciccoli, Lucia
Favilli, Roberto
Hayek, Joussef
Leoncini, Silvia
Signorini, Cinzia
Montomoli, Barbara
De Felice, Claudio
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rett syndrome (RTT) is a devastating neurodevelopmental disorder with a 300-fold increased risk rate for sudden cardiac death.
A subclinical myocardial biventricular dysfunction has been recently reported in RTT by our group and found to be associated with an enhanced oxidative stress (OS) status.
Here, we tested the effects of the naturally occurring antioxidants ω-3 polyunsaturated fatty acids (ω-3 PUFAs) on echocardiographic parameters and systemic OS markers in a population of RTT patients with the typical clinical form.
A total of 66 RTT girls were evaluated, half of whom being treated for 12 months with a dietary supplementation of ω-3 PUFAs at high dosage (docosahexaenoic acid ~71.9 ± 13.9 mg/kg b.w./day plus eicosapentaenoic acid ~115.5 ± 22.4 mg/kg b.w./day) versus the remaining half untreated population.
Echocardiographic systolic longitudinal parameters of both ventricles, but not biventricular diastolic measures, improved following ω-3 PUFAs supplementation, with a parallel decrease in the OS markers levels.
No significant changes in the examined echocardiographic parameters nor in the OS markers were detectable in the untreated RTT population.
Our data indicate that ω-3 PUFAs are able to improve the biventricular myocardial systolic function in RTT and that this functional gain is partially mediated through a regulation of the redox balance.
American Psychological Association (APA)
Maffei, Silvia& De Felice, Claudio& Cannarile, Pierpaolo& Leoncini, Silvia& Signorini, Cinzia& Pecorelli, Alessandra…[et al.]. 2014. Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043950
Modern Language Association (MLA)
Maffei, Silvia…[et al.]. Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043950
American Medical Association (AMA)
Maffei, Silvia& De Felice, Claudio& Cannarile, Pierpaolo& Leoncini, Silvia& Signorini, Cinzia& Pecorelli, Alessandra…[et al.]. Effects of ω-3 PUFAs Supplementation on Myocardial Function and Oxidative Stress Markers in Typical Rett Syndrome. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043950