Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up
Joint Authors
Holmberg, Markus
Huhtala, Heini
Murtonen, Annukka
Sumelahti, Marja-Liisa
Elovaara, Irina
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Object.
Gender and disease course specific incidences were studied in high- and medium-risk regions of MS in Finland.
Methods.
Age- and gender-specific incidences with 95% CIs were calculated in 10-year periods from 1981 to 2010.
Poser diagnostic criteria were used and compared with the McDonald criteria from 2001 to 2010.
Association between age and diagnostic delay over time was assessed by using the Kruskal-Wallis test.
Results.
1419 (89%) RRMS and 198 (11%) PPMS cases were included.
RRMS incidence increased with the female to male ratio (F/M) from 4,2/105 (F/M 1.9) to 9,7 (2.3), while that of PPMS decreased from 1,2 (1.6) to 0,7 (1.2).
The use of McDonald criteria did not change the conclusion.
The decreasing diagnostic delay and age at diagnosis in RRMS were associated within the 10-year periods and contrasted those in PPMS.
Increasing female risk in RRMS was observed in the high-risk region.
Conclusion.
Increasing RRMS incidence and high female ratios shown in each age group indicate gender-specific influences acting already from childhood.
A more precise definition of the risk factors and their action in MS is needed to provide a better understanding of underlying pathological processes and a rationale for the development of new preventive and treatment strategies.
American Psychological Association (APA)
Sumelahti, Marja-Liisa& Holmberg, Markus& Murtonen, Annukka& Huhtala, Heini& Elovaara, Irina. 2014. Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046593
Modern Language Association (MLA)
Sumelahti, Marja-Liisa…[et al.]. Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up. Multiple Sclerosis International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046593
American Medical Association (AMA)
Sumelahti, Marja-Liisa& Holmberg, Markus& Murtonen, Annukka& Huhtala, Heini& Elovaara, Irina. Increasing Incidence in Relapsing-Remitting MS and High Rates among Young Women in Finland: A Thirty-Year Follow-Up. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046593