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Outcome Measures in Relapsing-Remitting Multiple Sclerosis: Capturing Disability and Disease Progression in Clinical Trials
Joint Authors
Lavery, Amy M.
Verhey, Leonard H.
Waldman, Amy
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease that manifests as acute relapses and progressive disability.
As a primary endpoint for clinical trials in MS, disability is difficult to both characterize and measure.
Furthermore, the recovery from relapses and the rate of disability vary considerably among patients.
Given these challenges, investigators have developed and studied the performance of various outcome measures and surrogate endpoints in MS clinical trials.
This review defines the outcome measures and surrogate endpoints used to date in MS clinical trials and presents challenges in the design of both adult and pediatric trials.
American Psychological Association (APA)
Lavery, Amy M.& Verhey, Leonard H.& Waldman, Amy. 2014. Outcome Measures in Relapsing-Remitting Multiple Sclerosis: Capturing Disability and Disease Progression in Clinical Trials. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046595
Modern Language Association (MLA)
Lavery, Amy M.…[et al.]. Outcome Measures in Relapsing-Remitting Multiple Sclerosis: Capturing Disability and Disease Progression in Clinical Trials. Multiple Sclerosis International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1046595
American Medical Association (AMA)
Lavery, Amy M.& Verhey, Leonard H.& Waldman, Amy. Outcome Measures in Relapsing-Remitting Multiple Sclerosis: Capturing Disability and Disease Progression in Clinical Trials. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046595