Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis
Joint Authors
Dimisianos, Nikolaos
Rodi, Maria
Kalavrizioti, Dimitra
Georgiou, Vasileios
Papathanasopoulos, Panagiotis
Mouzaki, Athanasia
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
MS patients show a remarkable heterogeneity in their response to disease modifying treatments.
Given the need for early treatment initiation and the diversity of available options, a predictive marker that indicates good or poor response to treatment is highly desirable.
Objective.
To find a biomarker for treatment response to IFNβ among pro- and anti-inflammatory cytokines.
Materials and Methods.
IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17A, and TGF-β1 levels were measured in serum and CSF of 43 patients with RR-MS who were followed up for a mean period of 5.3 years.
Thirty-five patients received IFNβ treatment and were divided into good responders (GR, n = 19) and poor responders (PR, n = 16).
The remaining 8 patients showed a very favorable outcome and remained untreated (noRx).
Results.
GR had significantly higher serum baseline levels of IL-17A than PR and significantly higher serum levels of IL-17A, IFN-γ, TNF-α, and IL-2 than noRx.
PR had significantly higher IFN-γ serum levels than noRx.
No significant differences were observed in serum levels of IL-6, IL-4, IL-10, and TGF-β1 or the levels of all cytokines measured in CSF between the 3 groups of patients.
Conclusions.
Baseline serum levels of IL-17A can be used as a biomarker of IFNβ treatment response.
American Psychological Association (APA)
Dimisianos, Nikolaos& Rodi, Maria& Kalavrizioti, Dimitra& Georgiou, Vasileios& Papathanasopoulos, Panagiotis& Mouzaki, Athanasia. 2014. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046598
Modern Language Association (MLA)
Dimisianos, Nikolaos…[et al.]. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046598
American Medical Association (AMA)
Dimisianos, Nikolaos& Rodi, Maria& Kalavrizioti, Dimitra& Georgiou, Vasileios& Papathanasopoulos, Panagiotis& Mouzaki, Athanasia. Cytokines as Biomarkers of Treatment Response to IFNβ in Relapsing-Remitting Multiple Sclerosis. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046598
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046598