Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls
Joint Authors
Kister, Ilya
Bacon, Joshua H.
Bacon, Tamar E.
Pasternak, Eliana
Strauchler, Yael
Herbert, Joseph
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
There is an urgent need to develop a practical and reliable clinical measure of disease progression in early and mild MS.
We hypothesized that a test of sound lateralization, which is exquisitely sensitive to transmission delays in auditory brainstem, could be more useful for detecting processing speed deficits in mildly impaired MS subjects than standard cognitive tasks.
Objective.
To develop a practical test of sound lateralization for the clinic and to compare performance of MS subjects with variable disability and healthy subjects on Sound Lateralization Test (SLT) and two speed-of-processing tasks.
Design.
42 healthy controls and 90 subjects with clinically definite MS, divided into no, mild, and moderate disability strata, were administered the Symbol Digit Modalities Test (SDMT), and 3-second Paced Auditory Serial Addition Test (PASAT).
Results.
All of the tests showed an overall difference in performance between controls and the three MS groups, but only the SLT measured a significant difference between controls and the no disability group.
Conclusion.
SLT is rapidly applied, technically simple, and superior to standard processing speed tests for discriminating between healthy controls and nondisabled MS subjects.
SLT should be investigated as an outcome measure in early-phase trials and for monitoring early disease progression in the clinic.
American Psychological Association (APA)
Bacon, Joshua H.& Kister, Ilya& Bacon, Tamar E.& Pasternak, Eliana& Strauchler, Yael& Herbert, Joseph. 2014. Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046600
Modern Language Association (MLA)
Bacon, Joshua H.…[et al.]. Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls. Multiple Sclerosis International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1046600
American Medical Association (AMA)
Bacon, Joshua H.& Kister, Ilya& Bacon, Tamar E.& Pasternak, Eliana& Strauchler, Yael& Herbert, Joseph. Sound Lateralization Test Distinguishes Unimpaired MS Patients from Healthy Controls. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046600