The Prevalence of Familial Multiple Sclerosis in Saskatoon, Saskatchewan
Joint Authors
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
A population-based prevalent cohort of 150 clinical definite multiple sclerosis (MS) cases (102 women; 48 men) ascertained on January 1, 1977, Saskatoon, Saskatchewan, was found to have a familial rate of MS as 17.3%.
Objectives.
To determine the occurrence of familial MS cases and the frequency of MS among the biological relatives of the study cohort.
Methods.
The search for new familial cases MS affected relatives continued for 35 years until 2012.
The natural history of the disease of sporadic cases is compared with that of the familial cases.
SPSS V19 and Kaplan-Meier survival analysis were used for data analysis.
Results.
Of the 150 unrelated MS patients, 49 cases (32.7%) (36 women and 13 men) were reported of having at least one family member with MS.
There were a total of 86 affected relatives, 26 (30.2%) first-degree relatives, 15 (17.4%) second-degree relatives, 20 (23.3%) third-degree relatives, and 25 (29.1%) distant relatives.
The average age of MS onset for men with sporadic MS was 33.9 (SD = 10) years and 27.6 (SD = 8.4) years for familial cases and 29.3 (SD = 8.3) years and 26.8 (SD = 8.5) years for women.
Conclusion.
This 35-year longitudinal natural history study reveals a high frequency of cases with family members developing MS and supports a genetic influence in the etiology of MS.
American Psychological Association (APA)
Hader, Walter J.& Yee, Irene M.. 2014. The Prevalence of Familial Multiple Sclerosis in Saskatoon, Saskatchewan. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046603
Modern Language Association (MLA)
Hader, Walter J.& Yee, Irene M.. The Prevalence of Familial Multiple Sclerosis in Saskatoon, Saskatchewan. Multiple Sclerosis International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046603
American Medical Association (AMA)
Hader, Walter J.& Yee, Irene M.. The Prevalence of Familial Multiple Sclerosis in Saskatoon, Saskatchewan. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046603