Impact of a 5-Day Expedition to Machu Picchu on Persons with Multiple Sclerosis

Abstract EN

Persons with multiple sclerosis (MS) are less physically active than nondiseased persons and often report low self-efficacy levels.

In the context of an awareness project to promote physical activity and participation in MS, we addressed the impact of training for and participation in a unique expedition.

Medical events, relapses, and self-reported neurological worsening were followed from 6 months before and up to 4 months afterwards.

Validated patient-reported outcome measures were used to assess fatigue, self-efficacy in exercising, walking abilities, and illness perception.

Nine participants completed the training, expedition, and observational study.

Minor events, relapses, and/or neurological worsening were reported in six participants.

The three participants with mild disability and no cardiovascular risk factors or comorbidities were free of medical and neurological events.

We found a significant reduction of motor fatigue at last when compared with the first assessment.

The reduction tended to be more evident in participants with mild disability (Expanded Disability Status Scale (EDSS) <4 at baseline).

Cognitive fatigue, self-efficacy, and self-reported walking abilities did not change significantly.

Illness perceptions tended to be reduced over time in the domains of consequences, identity, and concerns.

Overall, no major adverse events occurred.