Oral Dalfampridine Improves Standing Balance Detected at Static Posturography in Multiple Sclerosis
Joint Authors
Giannì, Costanza
Fortuna, Deborah
Marchetti, Maria Rita
Pozzilli, Carlo
Prosperini, Luca
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report a 14-week post-marketing experience on 20 patients with multiple sclerosis (MS) who started prolonged-release (PR) oral dalfampridine 10 mg twice daily according to European Medicine Agency criteria.
They underwent serial static posturography assessments and the dizziness handicap inventory (DHI) to investigate whether PR dalfampridine could impact standing balance and self-reported perception of balance.
The incidence of accidental falls per person per month was also recorded throughout the study.
Eight (40%) patients, who had a relevant improvement in walking speed, were defined as treatment responders.
They showed a significant improvement of standing balance (with respect to pretreatment assessment) when contrasted with 12 (60%) nonresponders ( F [ 4 , 15 ] = 3.959, P = 0.027 ).
No significant changes in DHI score, as well as in its functional, physical, and emotional subscales, were found in both responders and nonresponders at the end of study (all P values are ≥0.2).
Treatment response did not affect the incidence of accidental falls.
Future studies based on larger sample sizes, and with longer followup, are required to confirm the beneficial effect of PR dalfampridine on standing balance.
American Psychological Association (APA)
Prosperini, Luca& Giannì, Costanza& Fortuna, Deborah& Marchetti, Maria Rita& Pozzilli, Carlo. 2014. Oral Dalfampridine Improves Standing Balance Detected at Static Posturography in Multiple Sclerosis. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046617
Modern Language Association (MLA)
Prosperini, Luca…[et al.]. Oral Dalfampridine Improves Standing Balance Detected at Static Posturography in Multiple Sclerosis. Multiple Sclerosis International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1046617
American Medical Association (AMA)
Prosperini, Luca& Giannì, Costanza& Fortuna, Deborah& Marchetti, Maria Rita& Pozzilli, Carlo. Oral Dalfampridine Improves Standing Balance Detected at Static Posturography in Multiple Sclerosis. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046617