Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis
Joint Authors
Rao, S. M.
Martin, A. L.
Huelin, R.
Wissinger, E.
Khankhel, Z.
Kim, E.
Fahrbach, K.
Source
Multiple Sclerosis International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT).
Methods.
A systematic literature review was conducted.
Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy.
Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial testing to detect trends when comparing correlation strengths of SDMT versus PASAT and T2LV versus atrophy were conducted.
Results.
The 39 studies identified frequently reported only significant correlations, suggesting reporting bias.
Direct meta-analysis was only feasible for correlations between SDMT and T2LV ( r = - 0.45 , P < 0.001 ) and atrophy in patients with mixed-MS subtypes ( r = - 0.54 , P < 0.001 ).
Familywise Holm-Bonferroni testing found that selective reporting was not the source of at least half of significant results reported.
Binomial tests ( P = 0.006 ) favored SDMT over PASAT in strength of MRI correlations.
Conclusions.
A moderate-to-strong correlation exists between impaired IPS and MRI in mixed MS populations.
Correlations with MRI were stronger for SDMT than for PASAT.
Neither heterogeneity among populations nor reporting bias appeared to be responsible for these findings.
American Psychological Association (APA)
Rao, S. M.& Martin, A. L.& Huelin, R.& Wissinger, E.& Khankhel, Z.& Kim, E.…[et al.]. 2014. Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis. Multiple Sclerosis International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046622
Modern Language Association (MLA)
Rao, S. M.…[et al.]. Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis. Multiple Sclerosis International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046622
American Medical Association (AMA)
Rao, S. M.& Martin, A. L.& Huelin, R.& Wissinger, E.& Khankhel, Z.& Kim, E.…[et al.]. Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis. Multiple Sclerosis International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046622