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Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus
Joint Authors
Lehner, Astrid
Langguth, Berthold
Poeppl, Timm B.
Rupprecht, Rainer
Hajak, Göran
Landgrebe, Michael
Schecklmann, Martin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Repetitive transcranial magnetic stimulation (rTMS) of the temporal cortex has been used to treat patients with subjective tinnitus.
While rTMS is known to induce morphological changes in healthy subjects, no study has investigated yet whether rTMS treatment induces grey matter (GM) changes in tinnitus patients as well, whether these changes are correlated with treatment success, and whether GM at baseline is a useful predictor for treatment outcome.
Therefore, we examined magnetic resonance images of 77 tinnitus patients who were treated with rTMS of the left temporal cortex (10 days, 2000 stimuli/day, 1 Hz).
At baseline and after the last treatment session high-resolution structural images of the brain were acquired and tinnitus severity was assessed.
For a subgroup of 41 patients, additional brain scans were done after a follow-up period of 90 days.
GM changes were analysed by means of voxel based morphometry.
Transient GM decreases were detectable in several brain regions, especially in the insula and the inferior frontal cortex.
These changes were not related to treatment outcome though.
Baseline images correlated with change in tinnitus severity in the frontal cortex and the lingual gyrus, suggesting that GM at baseline might hold potential as a possible predictor for treatment outcome.
American Psychological Association (APA)
Lehner, Astrid& Langguth, Berthold& Poeppl, Timm B.& Rupprecht, Rainer& Hajak, Göran& Landgrebe, Michael…[et al.]. 2014. Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus. Neural Plasticity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046633
Modern Language Association (MLA)
Lehner, Astrid…[et al.]. Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus. Neural Plasticity No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046633
American Medical Association (AMA)
Lehner, Astrid& Langguth, Berthold& Poeppl, Timm B.& Rupprecht, Rainer& Hajak, Göran& Landgrebe, Michael…[et al.]. Structural Brain Changes Following Left Temporal Low-Frequency rTMS in Patients with Subjective Tinnitus. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046633