Astrocyte-Synapse Structural Plasticity
Joint Authors
Nikonenko, Irina
Bernardinelli, Yann
Muller, Dominique
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The function and efficacy of synaptic transmission are determined not only by the composition and activity of pre- and postsynaptic components but also by the environment in which a synapse is embedded.
Glial cells constitute an important part of this environment and participate in several aspects of synaptic functions.
Among the glial cell family, the roles played by astrocytes at the synaptic level are particularly important, ranging from the trophic support to the fine-tuning of transmission.
Astrocytic structures are frequently observed in close association with glutamatergic synapses, providing a morphological entity for bidirectional interactions with synapses.
Experimental evidence indicates that astrocytes sense neuronal activity by elevating their intracellular calcium in response to neurotransmitters and may communicate with neurons.
The precise role of astrocytes in regulating synaptic properties, function, and plasticity remains however a subject of intense debate and many aspects of their interactions with neurons remain to be investigated.
A particularly intriguing aspect is their ability to rapidly restructure their processes and modify their coverage of the synaptic elements.
The present review summarizes some of these findings with a particular focus on the mechanisms driving this form of structural plasticity and its possible impact on synaptic structure and function.
American Psychological Association (APA)
Bernardinelli, Yann& Muller, Dominique& Nikonenko, Irina. 2014. Astrocyte-Synapse Structural Plasticity. Neural Plasticity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046664
Modern Language Association (MLA)
Bernardinelli, Yann…[et al.]. Astrocyte-Synapse Structural Plasticity. Neural Plasticity No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1046664
American Medical Association (AMA)
Bernardinelli, Yann& Muller, Dominique& Nikonenko, Irina. Astrocyte-Synapse Structural Plasticity. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046664