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Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats
Joint Authors
Chen, Peng-zhi
Jiang, Hui-hui
Wen, Bo
Ren, Shuan-cheng
Chen, Yang
Ji, Wei-gang
Hu, Bo
Zhang, Jun
Xu, Fenglian
Zhu, Zhi-ru
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Accumulated soluble amyloid beta- (Aβ-) induced aberrant neuronal network activity may directly contribute to cognitive deficits, which are the most outstanding characteristics of Alzheimer’s disease (AD).
The entorhinal cortex (EC) is one of the earliest affected brain regions in AD.
Impairments of EC neurons are responsible for the cognitive deficits in AD.
However, little effort has been made to investigate the effects of soluble Aβ on the discharge properties of EC neurons in vivo.
The present study was designed to examine the effects of soluble Aβ1−42 on the discharge properties of EC neurons, using in vivo extracellular single unit recordings.
The protective effects of gastrodin (GAS) were also investigated against Aβ1−42-induced alterations in EC neuronal activities.
The results showed that the spontaneous discharge of EC neurons was increased by local application of soluble Aβ1−42 and that GAS can effectively reverse Aβ1−42-induced facilitation of spontaneous discharge in a concentration-dependent manner.
Moreover, whole-cell patch clamp results indicated that the protective function of GAS on abnormal hyperexcitability may be partially mediated by its inhibitory action on Aβ1−42-elicited inward currents in EC neurons.
Our study suggested that GAS may provide neuroprotective effects on Aβ1−42-induced hyperactivity in EC neurons of rats.
American Psychological Association (APA)
Chen, Peng-zhi& Jiang, Hui-hui& Wen, Bo& Ren, Shuan-cheng& Chen, Yang& Ji, Wei-gang…[et al.]. 2014. Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats. Neural Plasticity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046677
Modern Language Association (MLA)
Chen, Peng-zhi…[et al.]. Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats. Neural Plasticity No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046677
American Medical Association (AMA)
Chen, Peng-zhi& Jiang, Hui-hui& Wen, Bo& Ren, Shuan-cheng& Chen, Yang& Ji, Wei-gang…[et al.]. Gastrodin Suppresses the Amyloid β-Induced Increase of Spontaneous Discharge in the Entorhinal Cortex of Rats. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046677