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Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development
Joint Authors
Tziridis, Konstantin
Korn, Sabine
Ahlf, Sönke
Schulze, Holger
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-27, 27 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
27
Main Subjects
Abstract EN
Noise-induced hearing loss (NIHL) and resulting comorbidities like subjective tinnitus are common diseases in modern societies.
A substance shown to be effective against NIHL in an animal model is the Ginkgo biloba extract EGb 761.
Further effects of the extract on the cellular and systemic levels of the nervous system make it a promising candidate not only for protection against NIHL but also for its secondary comorbidities like tinnitus.
Following an earlier study we here tested the potential effectiveness of prophylactic EGb 761 treatment against NIHL and tinnitus development in the Mongolian gerbil.
We monitored the effects of EGb 761 and noise trauma-induced changes on signal processing within the auditory system by means of behavioral and electrophysiological approaches.
We found significantly reduced NIHL and tinnitus development upon EGb 761 application, compared to vehicle treated animals.
These protective effects of EGb 761 were correlated with changes in auditory processing, both at peripheral and central levels.
We propose a model with two main effects of EGb 761 on auditory processing, first, an increase of auditory brainstem activity leading to an increased thalamic input to the primary auditory cortex (AI) and second, an asymmetric effect on lateral inhibition in AI.
American Psychological Association (APA)
Tziridis, Konstantin& Korn, Sabine& Ahlf, Sönke& Schulze, Holger. 2014. Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development. Neural Plasticity،Vol. 2014, no. 2014, pp.1-27.
https://search.emarefa.net/detail/BIM-1046686
Modern Language Association (MLA)
Tziridis, Konstantin…[et al.]. Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development. Neural Plasticity No. 2014 (2014), pp.1-27.
https://search.emarefa.net/detail/BIM-1046686
American Medical Association (AMA)
Tziridis, Konstantin& Korn, Sabine& Ahlf, Sönke& Schulze, Holger. Protective Effects of Ginkgo biloba Extract EGb 761 against Noise Trauma-Induced Hearing Loss and Tinnitus Development. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-27.
https://search.emarefa.net/detail/BIM-1046686
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046686