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Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap
Joint Authors
Thuret, Sandrine
Murphy, Tytus
Dias, Gisele Pereira
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
Dietary interventions have emerged as effective environmental inducers of brain plasticity.
Among these dietary interventions, we here highlight the impact of caloric restriction (CR: a consistent reduction of total daily food intake), intermittent fasting (IF, every-other-day feeding), and diet supplementation with polyphenols and polyunsaturated fatty acids (PUFAs) on markers of brain plasticity in animal studies.
Moreover, we also discuss epidemiological and intervention studies reporting the effects of CR, IF and dietary polyphenols and PUFAs on learning, memory, and mood.
In particular, we evaluate the gap in mechanistic understanding between recent findings from animal studies and those human studies reporting that these dietary factors can benefit cognition, mood, and anxiety, aging, and Alzheimer’s disease—with focus on the enhancement of structural and functional plasticity markers in the hippocampus, such as increased expression of neurotrophic factors, synaptic function and adult neurogenesis.
Lastly, we discuss some of the obstacles to harnessing the promising effects of diet on brain plasticity in animal studies into effective recommendations and interventions to promote healthy brain function in humans.
Together, these data reinforce the important translational concept that diet, a modifiable lifestyle factor, holds the ability to modulate brain health and function.
American Psychological Association (APA)
Murphy, Tytus& Dias, Gisele Pereira& Thuret, Sandrine. 2014. Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap. Neural Plasticity،Vol. 2014, no. 2014, pp.1-32.
https://search.emarefa.net/detail/BIM-1046711
Modern Language Association (MLA)
Murphy, Tytus…[et al.]. Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap. Neural Plasticity No. 2014 (2014), pp.1-32.
https://search.emarefa.net/detail/BIM-1046711
American Medical Association (AMA)
Murphy, Tytus& Dias, Gisele Pereira& Thuret, Sandrine. Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-32.
https://search.emarefa.net/detail/BIM-1046711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046711