Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis
Joint Authors
Sierra, Amanda
Beccari, Sol
Diaz-Aparicio, Irune
Encinas, Juan M.
Comeau, Samuel
Tremblay, Marie-Ève
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Microglia cells are the major orchestrator of the brain inflammatory response.
As such, they are traditionally studied in various contexts of trauma, injury, and disease, where they are well-known for regulating a wide range of physiological processes by their release of proinflammatory cytokines, reactive oxygen species, and trophic factors, among other crucial mediators.
In the last few years, however, this classical view of microglia was challenged by a series of discoveries showing their active and positive contribution to normal brain functions.
In light of these discoveries, surveillant microglia are now emerging as an important effector of cellular plasticity in the healthy brain, alongside astrocytes and other types of inflammatory cells.
Here, we will review the roles of microglia in adult hippocampal neurogenesis and their regulation by inflammation during chronic stress, aging, and neurodegenerative diseases, with a particular emphasis on their underlying molecular mechanisms and their functional consequences for learning and memory.
American Psychological Association (APA)
Sierra, Amanda& Beccari, Sol& Diaz-Aparicio, Irune& Encinas, Juan M.& Comeau, Samuel& Tremblay, Marie-Ève. 2014. Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis. Neural Plasticity،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1046724
Modern Language Association (MLA)
Sierra, Amanda…[et al.]. Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis. Neural Plasticity No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-1046724
American Medical Association (AMA)
Sierra, Amanda& Beccari, Sol& Diaz-Aparicio, Irune& Encinas, Juan M.& Comeau, Samuel& Tremblay, Marie-Ève. Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-1046724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046724