NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation
Joint Authors
Rohde, Marco
Köhling, Rüdiger
Kirschstein, Timo
Tokay, Tursonjan
Zschorlich, Volker
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses.
Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings.
In control slices, electrical high-frequency conditioning stimulation (CS) could reliably induce LTP.
In contrast, the same CS protocol resulted in long-term depression when HFMS was delivered to the slice 30 min prior to the electrical stimulation.
HFMS-priming was diminished when applied in the presence of the metabotropic glutamate receptor antagonists (RS)-α-methylserine-O-phosphate (MSOP) and (RS)-α-methyl-4-carboxyphenylglycine (MCPG).
Moreover, when HFMS was delivered in the presence of the NMDA receptor-antagonist D-2-amino-5-phosphonovalerate (50 µM), CS-induced electrical LTP was again as high as under control conditions in slices without priming.
These results demonstrate that HFMS significantly reduced the propensity of subsequent electrical LTP and show that both metabotropic glutamate and NMDA receptor activation were involved in this form of HFMS-induced metaplasticity.
American Psychological Association (APA)
Tokay, Tursonjan& Kirschstein, Timo& Rohde, Marco& Zschorlich, Volker& Köhling, Rüdiger. 2014. NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation. Neural Plasticity،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046735
Modern Language Association (MLA)
Tokay, Tursonjan…[et al.]. NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation. Neural Plasticity No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1046735
American Medical Association (AMA)
Tokay, Tursonjan& Kirschstein, Timo& Rohde, Marco& Zschorlich, Volker& Köhling, Rüdiger. NMDA Receptor-Dependent Metaplasticity by High-Frequency Magnetic Stimulation. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1046735
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046735