Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition
Joint Authors
Lucassen, Paul
Marlatt, Michael W.
Bauer, Jan
Aronica, Eleonora
van Haastert, Elise S.
Joels, Marian
Hoozemans, Jeroen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Microglia and astrocytes contribute to Alzheimer’s disease (AD) etiology and may mediate early neuroinflammatory responses.
Despite their possible role in disease progression and despite the fact that they can respond to amyloid deposition in model systems, little is known about whether astro- or microglia can undergo proliferation in AD and whether this is related to the clinical symptoms or to local neuropathological changes.
Previously, proliferation was found to be increased in glia-rich regions of the presenile hippocampus.
Since their phenotype was unknown, we here used two novel triple-immunohistochemical protocols to study proliferation in astro- or microglia in relation to amyloid pathology.
We selected different age-matched cohorts to study whether proliferative changes relate to clinical severity or to neuropathological changes.
Proliferating cells were found across the hippocampus but never in mature neurons or astrocytes.
Almost all proliferating cells were colabeled with Iba1+, indicating that particularly microglia contribute to proliferation in AD.
Proliferating Iba1+ cells was specifically seen within the borders of amyloid plaques, indicative of an active involvement in, or response to, plaque accumulation.
Thus, consistent with animal studies, proliferation in the AD hippocampus is due to microglia, occurs in close proximity of plaque pathology, and may contribute to the neuroinflammation common in AD.
American Psychological Association (APA)
Marlatt, Michael W.& Bauer, Jan& Aronica, Eleonora& van Haastert, Elise S.& Hoozemans, Jeroen& Joels, Marian…[et al.]. 2014. Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition. Neural Plasticity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046736
Modern Language Association (MLA)
Marlatt, Michael W.…[et al.]. Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition. Neural Plasticity No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046736
American Medical Association (AMA)
Marlatt, Michael W.& Bauer, Jan& Aronica, Eleonora& van Haastert, Elise S.& Hoozemans, Jeroen& Joels, Marian…[et al.]. Proliferation in the Alzheimer Hippocampus Is due to Microglia, Not Astroglia, and Occurs at Sites of Amyloid Deposition. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046736
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046736