Animal Models of Subjective Tinnitus
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Tinnitus is one of the major audiological diseases, affecting a significant portion of the ageing society.
Despite its huge personal and presumed economic impact there are only limited therapeutic options available.
The reason for this deficiency lies in the very nature of the disease as it is deeply connected to elementary plasticity of auditory processing in the central nervous system.
Understanding these mechanisms is essential for developing a therapy that reverses the plastic changes underlying the pathogenesis of tinnitus.
This requires experiments that address individual neurons and small networks, something usually not feasible in human patients.
However, in animals such invasive experiments on the level of single neurons with high spatial and temporal resolution are possible.
Therefore, animal models are a very critical element in the combined efforts for engineering new therapies.
This review provides an overview over the most important features of animal models of tinnitus: which laboratory species are suitable, how to induce tinnitus, and how to characterize the perceived tinnitus by behavioral means.
In particular, these aspects of tinnitus animal models are discussed in the light of transferability to the human patients.
American Psychological Association (APA)
von der Behrens, Wolfger. 2014. Animal Models of Subjective Tinnitus. Neural Plasticity،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046738
Modern Language Association (MLA)
von der Behrens, Wolfger. Animal Models of Subjective Tinnitus. Neural Plasticity No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1046738
American Medical Association (AMA)
von der Behrens, Wolfger. Animal Models of Subjective Tinnitus. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1046738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046738