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Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu
Joint Authors
Kral, John G.
Syed, Shariful
Fulton, Sasha L.
Banerji, Mary Ann
Dwork, Andrew J.
Perera, Tarique D.
Coplan, Jeremy D.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glucagon-like peptide-1 (GLP-1) regulates carbohydrate metabolism and promotes neurogenesis.
We reported an inverse correlation between adult body mass and neurogenesis in nonhuman primates.
Here we examine relationships between physiological levels of the neurotrophic incretin, plasma GLP-1 (pGLP-1), and body mass index (BMI) in adolescence to adult neurogenesis and associations with a diabesity diathesis and infant stress.
Morphometry, fasting pGLP-1, insulin resistance, and lipid profiles were measured in early adolescence in 10 stressed and 4 unstressed male bonnet macaques.
As adults, dentate gyrus neurogenesis was assessed by doublecortin staining.
High pGLP-1, low body weight, and low central adiposity, yet peripheral insulin resistance and high plasma lipids, during adolescence were associated with relatively high adult neurogenesis rates.
High pGLP-1 also predicted low body weight with, paradoxically, insulin resistance and high plasma lipids.
No rearing effects for neurogenesis rates were observed.
We replicated an inverse relationship between BMI and neurogenesis.
Adolescent pGLP-1 directly predicted adult neurogenesis.
Two divergent processes relevant to human diabesity emerge—high BMI, low pGLP-1, and low neurogenesis and low BMI, high pGLP-1, high neurogenesis, insulin resistance, and lipid elevations.
Diabesity markers putatively reflect high nutrient levels necessary for neurogenesis at the expense of peripheral tissues.
American Psychological Association (APA)
Coplan, Jeremy D.& Syed, Shariful& Perera, Tarique D.& Fulton, Sasha L.& Banerji, Mary Ann& Dwork, Andrew J.…[et al.]. 2014. Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu. Neural Plasticity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046746
Modern Language Association (MLA)
Coplan, Jeremy D.…[et al.]. Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu. Neural Plasticity No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046746
American Medical Association (AMA)
Coplan, Jeremy D.& Syed, Shariful& Perera, Tarique D.& Fulton, Sasha L.& Banerji, Mary Ann& Dwork, Andrew J.…[et al.]. Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu. Neural Plasticity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046746