Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation
Joint Authors
Yueniwati, Yuyun
Yurina, Valentina
Indra, Mohammad Rasjad
Source
Neurology Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Carotid intima media thickness (CIMT) is clearly associated with atherosclerosis.
Studies in ischemic stroke patients reveal that there is a significant association between CIMT with monocyte chemoattractant protein-1 (MCP-1) and osteopontin (OPN) promoter polymorphism.
This research aims to explain the effect of MCP-1 and OPN promoter polymorphism toward CIMT changes identified in Javanese Indonesian children.
Subjects were 54 children: 27 were from parents with ischemic stroke (cases), and 27 were from healthy parents (controlled).
The CIMT was examined by utilizing high resolution B-mode ultrasound.
Physical examination and genotyping analysis of MCP-1 promoter were conducted by employing PCR method.
Research results indicate that two polymorphisms were obtained, that is, A-2138T and G-2464A, respectively.
A-2138T polymorphism was found in 5% of case children and in 14.3% of controlled children.
G-2464A polymorphism was found in 5% of case children.
CIMT of case children was significantly different from that of controlled children (0.61±0.012 mm versus, 0.52±0.015 mm, P= 0.021).
Subjects with MCP-1 promoter polymorphism have 1.471 times higher tendency to have thicker CIMT than subjects with no polymorphism in MCP1 promoter.
OPN promoter T-66G was also studied but it did not indicate occurrence of polymorphism in samples.
American Psychological Association (APA)
Yueniwati, Yuyun& Yurina, Valentina& Indra, Mohammad Rasjad. 2014. Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation. Neurology Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1046766
Modern Language Association (MLA)
Yueniwati, Yuyun…[et al.]. Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation. Neurology Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1046766
American Medical Association (AMA)
Yueniwati, Yuyun& Yurina, Valentina& Indra, Mohammad Rasjad. Thicker Carotid Intima Media Thickness in Children with Monocyte Chemoattractant Protein-1: A-2138T and A-2464G Mutation. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1046766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046766