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Apathy in Parkinson’s Disease: An Electrophysiological Study
Joint Authors
Neau, Jean-Philippe
Pluchon, Claudette
Fargeau, Marie-Noëlle
Karolewicz, Stéphane
Gil, Roger
Mathis, Stéphane
Iljicsov, Anna
Source
Neurology Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In Parkinson’s disease (PD), apathy (or loss of motivation) is frequent.
Nevertheless, the contribution of attentional disorders to its genesis is still not clearly known.
We want to determine the relation existing between apathy and attentional disorders by using P300a (or novelty P3) as a marker of the attentional process.
The study included 25 patients (13 women and 12 men) with PD for whom we have determined the relationship between automatic attention (represented by P300a) and motor status, apathy, executive dysfunction, mental flexibility, inhibitory control, and depression/anxiety.
We have found a correlation between the apathy score and amplitude of novelty P300 during the ON period and also a correlation of the apathy score with a decrease in amplitude of P300 during the OFF period.
In a linear regression model, changes in the P300a predicted the severity of apathy independently of any other variable.
We concluded firstly that the reduction in amplitude of the P300a wave was a neurophysiological marker of apathy in PD and secondly that apathy led to both dopaminergic denervation (mesolimbic) and nondopaminergic (dorsolateral prefrontal-subcortical) dysfunction.
American Psychological Association (APA)
Mathis, Stéphane& Neau, Jean-Philippe& Pluchon, Claudette& Fargeau, Marie-Noëlle& Karolewicz, Stéphane& Iljicsov, Anna…[et al.]. 2014. Apathy in Parkinson’s Disease: An Electrophysiological Study. Neurology Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046778
Modern Language Association (MLA)
Mathis, Stéphane…[et al.]. Apathy in Parkinson’s Disease: An Electrophysiological Study. Neurology Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046778
American Medical Association (AMA)
Mathis, Stéphane& Neau, Jean-Philippe& Pluchon, Claudette& Fargeau, Marie-Noëlle& Karolewicz, Stéphane& Iljicsov, Anna…[et al.]. Apathy in Parkinson’s Disease: An Electrophysiological Study. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046778