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Desmopressin Acetate in Intracranial Haemorrhage
Joint Authors
Kapapa, Thomas
Röhrer, Stefan
Struve, Sabine
Petscher, Matthias
König, Ralph
Wirtz, Christian Rainer
Woischneck, Dieter
Source
Neurology Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-12-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
The secondary increase in the size of intracranial haematomas as a result of spontaneous haemorrhage or trauma is of particular relevance in the event of prior intake of platelet aggregation inhibitors.
We describe the effect of desmopressin acetate as a means of temporarily stabilising the platelet function.
Patients and Methods.
The platelet function was analysed in 10 patients who had received single ( N = 4 ) or multiple ( N = 6 ) doses of acetylsalicylic acid and 3 patients (control group) who had not taken acetylsalicylic acid.
All subjects had suffered intracranial haemorrhage.
Analysis was performed before, half an hour and three hours after administration of desmopressin acetate.
Statistical analysis was performed by applying a level of significance of P ≤ 0.05 .
Results.
(1) Platelet function returned to normal 30 minutes after administration of desmopressin acetate.
(2) The platelet function worsened again after three hours.
(3) There were no complications related to electrolytes or fluid balance.
Conclusion.
Desmopressin acetate can stabilise the platelet function in neurosurgical patients who have received acetylsalicylic acid prior to surgery without causing transfusion-related side effects or a loss of time.
The effect is, however, limited and influenced by the frequency of drug intake.
Further controls are needed in neurosurgical patients.
American Psychological Association (APA)
Kapapa, Thomas& Röhrer, Stefan& Struve, Sabine& Petscher, Matthias& König, Ralph& Wirtz, Christian Rainer…[et al.]. 2014. Desmopressin Acetate in Intracranial Haemorrhage. Neurology Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046783
Modern Language Association (MLA)
Kapapa, Thomas…[et al.]. Desmopressin Acetate in Intracranial Haemorrhage. Neurology Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046783
American Medical Association (AMA)
Kapapa, Thomas& Röhrer, Stefan& Struve, Sabine& Petscher, Matthias& König, Ralph& Wirtz, Christian Rainer…[et al.]. Desmopressin Acetate in Intracranial Haemorrhage. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046783
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046783