Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement
Joint Authors
Ashrafian, Hutan
Kidher, Emaddin
Patel, Vanash M.
Nihoyannopoulos, Petros
Anderson, Jon R.
Chukwuemeka, Andrew
Francis, Darrel P.
Athanasiou, Thanos
Source
Neurology Research International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells.
The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed.
Methods.
Patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) had their PWV and NR2Ab serum levels measured preoperatively.
We analyzed PWV and NR2Ab in two ways: (1) as continuous variables using the actual value and (2) as dichotomous variables (PWV-norm and PWV-high groups) and (NR2Ab-low and NR2Ab-high groups).
Results.
Fifty-six patients ( 71 ± 8.4 years) were included in this study.
The NR2Ab level (ng/mL) was significantly higher in the PWV-high group ( n = 21 ) than in PWV-norm group ( n = 35 ; median 1.8 ± 1.2 versus 1.2 ± 0.7 , resp., P = 0.003 ).
NR2Ab level was positively associated with PWV and negatively associated with male gender.
Multiple regression revealed PWV independently related to NR2Ab level, and PWV cut-off was associated with a 7.23 times increase in the likelihood of having high NR2Ab (>1.8 ng/mL).
Conclusion.
Higher PWV in patients with surgical aortic stenosis is associated with higher levels of the ischemic brain biomarker NR2Ab.
American Psychological Association (APA)
Kidher, Emaddin& Patel, Vanash M.& Nihoyannopoulos, Petros& Anderson, Jon R.& Chukwuemeka, Andrew& Francis, Darrel P.…[et al.]. 2014. Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement. Neurology Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046811
Modern Language Association (MLA)
Kidher, Emaddin…[et al.]. Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement. Neurology Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046811
American Medical Association (AMA)
Kidher, Emaddin& Patel, Vanash M.& Nihoyannopoulos, Petros& Anderson, Jon R.& Chukwuemeka, Andrew& Francis, Darrel P.…[et al.]. Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement. Neurology Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046811