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The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance
Joint Authors
Sacchinelli, Angela
Di Cello, Annalisa
Lucia, Antonella
Rania, Erika
Cirillo, Roberto
Zullo, Fulvio
Venturella, Roberta
Lico, Daniela
Source
Obstetrics and Gynecology International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
Substances such as inositol and N-acetylcysteine (NAC) have been recently shown to be effective in treatment of PCOS patients.
The aim of this prospective trial is to evaluate the efficacy of NAC + Inositol + folic acid on ovulation rate and menstrual regularity in PCOS patients with and without insulin resistance.
Methods.
Among the 91 PCOS patients treated with NAC + Inositol + folic, insulin resistance was present in 44 subjects (A) and absent in 47 (B).
The primary endpoint was the ovulation rate/year, determined by menstrual diary, serum progesterone performed between 21° and 24° days, ultrasound findings of growth follicular or luteal cysts, and luteal ratio.
HOMA-index assessment after 6 and 12 months of treatment was evaluated as secondary endpoint.
Results.
In both groups there was a significant increase in ovulation rate and no significant differences were found in the primary outcome between two groups.
In group A, a significant reduction of HOMA-index was observed.
Conclusions.
The association NAC + Inositol + folic, regardless of insulin-resistance state, seems to improve ovarian function in PCOS patients.
Therefore, inositol and NAC may have additional noninsulin-related mechanisms of action that allow achieving benefits also in those patients with negative HOMA-index.
American Psychological Association (APA)
Sacchinelli, Angela& Venturella, Roberta& Lico, Daniela& Di Cello, Annalisa& Lucia, Antonella& Rania, Erika…[et al.]. 2014. The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance. Obstetrics and Gynecology International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046879
Modern Language Association (MLA)
Sacchinelli, Angela…[et al.]. The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance. Obstetrics and Gynecology International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1046879
American Medical Association (AMA)
Sacchinelli, Angela& Venturella, Roberta& Lico, Daniela& Di Cello, Annalisa& Lucia, Antonella& Rania, Erika…[et al.]. The Efficacy of Inositol and N-Acetyl Cysteine Administration (Ovaric HP) in Improving the Ovarian Function in Infertile Women with PCOS with or without Insulin Resistance. Obstetrics and Gynecology International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046879