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Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OBGYN Research Questions
Joint Authors
Santillan, Donna A.
Santillan, Mark K.
Onukwugha, Chinenye
Goodheart, Michael J.
Reyes, Henry D.
Leslie, Kimberly K.
Devor, Eric J.
Source
Obstetrics and Gynecology International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Placenta-specific protein 1 (PLAC1) is a secreted protein found in trophoblasts.
Several reports implicate a central role for PLAC1 in establishment and maintenance of the placenta.
In addition to placentae PLAC1 is expressed in a variety of solids including breast, endometrial, and ovarian cancers.
In order to show that PLAC1 is potentially relevant to a number of research questions in OB/GYN, we report on PLAC1 expression in a selected panel that includes two choriocarcinoma cell lines, normal placental tissues, and endometrial and ovarian tumors.
We report for the first time that PLAC1 is also expressed in human fetal tissues.
PLAC1 is transcriptionally heterogeneous with one promoter (P1) generating two transcripts with alternately spliced 5’ UTRs and the other promoter (P2) generating a third transcript.
Placental tissues favor P2 transcripts, while P1 is favored in most of the other cells.
Mechanisms determining multiple PLAC1 transcripts and promoter preferences are as yet unknown, but it is clear that this protein is likely to be important in a variety of phenomena relevant to both gynecologic oncology and maternal-fetal medicine.
American Psychological Association (APA)
Devor, Eric J.& Reyes, Henry D.& Santillan, Donna A.& Santillan, Mark K.& Onukwugha, Chinenye& Goodheart, Michael J.…[et al.]. 2014. Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OBGYN Research Questions. Obstetrics and Gynecology International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046915
Modern Language Association (MLA)
Devor, Eric J.…[et al.]. Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OBGYN Research Questions. Obstetrics and Gynecology International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1046915
American Medical Association (AMA)
Devor, Eric J.& Reyes, Henry D.& Santillan, Donna A.& Santillan, Mark K.& Onukwugha, Chinenye& Goodheart, Michael J.…[et al.]. Placenta-Specific Protein 1: A Potential Key to Many Oncofetal-Placental OBGYN Research Questions. Obstetrics and Gynecology International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1046915
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046915