Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy
Joint Authors
Romero, Francisco Javier
Muriach, María
Barcia, Jorge M.
Flores-Bellver, Miguel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not attributable to other causes, and shares many symptoms that are best described as accelerated brain ageing.
A common theory for aging and for the pathogenesis of this cerebral dysfunctioning in diabetes relates cell death to oxidative stress in strong association to inflammation, and in fact nuclear factor κB (NFκB), a master regulator of inflammation and also a sensor of oxidative stress, has a strategic position at the crossroad between oxidative stress and inflammation.
Moreover, metabolic inflammation is, in turn, related to the induction of various intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect.
In parallel, blockade of autophagy can relate to proinflammatory signaling via oxidative stress pathway and NFκB-mediated inflammation.
American Psychological Association (APA)
Muriach, María& Flores-Bellver, Miguel& Romero, Francisco Javier& Barcia, Jorge M.. 2014. Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046923
Modern Language Association (MLA)
Muriach, María…[et al.]. Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046923
American Medical Association (AMA)
Muriach, María& Flores-Bellver, Miguel& Romero, Francisco Javier& Barcia, Jorge M.. Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046923