Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models

Joint Authors

Zhao, Yun
Shu, Ping
Zhang, Youzhi
Lin, Limin
Zhou, Haihong
Xu, Zhentian
Suo, Daqin
Xie, Anzhi
Jin, Xin

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-04-16

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

Hyperlipidemia and many other metabolic diseases are related to oxidative stress.

Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported.

We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism.

Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect.

We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model.

It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels.

L-CAT and SR-BI gene expression in hamsters were increased.

Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties.

American Psychological Association (APA)

Zhao, Yun& Shu, Ping& Zhang, Youzhi& Lin, Limin& Zhou, Haihong& Xu, Zhentian…[et al.]. 2014. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046940

Modern Language Association (MLA)

Zhao, Yun…[et al.]. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046940

American Medical Association (AMA)

Zhao, Yun& Shu, Ping& Zhang, Youzhi& Lin, Limin& Zhou, Haihong& Xu, Zhentian…[et al.]. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046940

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1046940