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Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models
Joint Authors
Zhao, Yun
Shu, Ping
Zhang, Youzhi
Lin, Limin
Zhou, Haihong
Xu, Zhentian
Suo, Daqin
Xie, Anzhi
Jin, Xin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hyperlipidemia and many other metabolic diseases are related to oxidative stress.
Centella asiatica is a traditional Chinese medicine whose antioxidant effect in vitro has been reported.
We are interested in whether it possesses this effect in vivo and hence modulates lipid metabolism.
Therefore, experiments were carried out on mice and golden hamsters regarding its antioxidant and hypolipidemic effect.
We observed that a fraction (CAF3) of the ethanol extract (CAE) of Centella asiatica had a cholesterol decrease of 79% and a triglyceride decrease of 95% in acute mice model, so CAF3 was further investigated in high-fat-fed hamster model.
It was shown that CAF3 increased SOD and GSH-Px activities and decreased MDA level, and it also improved TC, TG, LDL-C, HDL-C, AST, and ALT levels.
L-CAT and SR-BI gene expression in hamsters were increased.
Taken together, our data suggest that the CAF3 fraction of Centella asiatica has antioxidant and hypolipidemic properties.
American Psychological Association (APA)
Zhao, Yun& Shu, Ping& Zhang, Youzhi& Lin, Limin& Zhou, Haihong& Xu, Zhentian…[et al.]. 2014. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046940
Modern Language Association (MLA)
Zhao, Yun…[et al.]. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046940
American Medical Association (AMA)
Zhao, Yun& Shu, Ping& Zhang, Youzhi& Lin, Limin& Zhou, Haihong& Xu, Zhentian…[et al.]. Effect of Centella asiatica on Oxidative Stress and Lipid Metabolism in Hyperlipidemic Animal Models. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046940