Propofol Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Expression and Myocardial Depression through Decreasing the Generation of Superoxide Anion in Cardiomyocytes
Joint Authors
Tang, Jing
Hu, Ji-Jie
Lu, Chun-Hua
Liang, Jia-Ni
Xiao, Jin-Fang
Liu, You-Tan
Lin, Chun-Shui
Qin, Zai-Sheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
TNF-α has been shown to be a major factor responsible for myocardial depression in sepsis.
The aim of this study was to investigate the effect of an anesthetic, propofol, on TNF-α expression in cardiomyocytes treated with LPS both in vivo and in vitro.
In cultured cardiomyocytes, compared with control group, propofol significantly reduced protein expression of gp91phox and phosphorylation of extracellular regulated protein kinases 1/2 (ERK1/2) and p38 MAPK, which associates with reduced TNF-α production.
In in vivo mice studies, propofol significantly improved myocardial depression and increased survival rate of mice after LPS treatment or during endotoxemia, which associates with reduced myocardial TNF-α production, gp91phox, ERK1/2, and p38 MAPK.
It is concluded that propofol abrogates LPS-induced TNF-α production and alleviates cardiac depression through gp91phox/ERK1/2 or p38 MAPK signal pathway.
These findings have great clinical importance in the application of propofol for patients enduring sepsis.
American Psychological Association (APA)
Tang, Jing& Hu, Ji-Jie& Lu, Chun-Hua& Liang, Jia-Ni& Xiao, Jin-Fang& Liu, You-Tan…[et al.]. 2014. Propofol Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Expression and Myocardial Depression through Decreasing the Generation of Superoxide Anion in Cardiomyocytes. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046944
Modern Language Association (MLA)
Tang, Jing…[et al.]. Propofol Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Expression and Myocardial Depression through Decreasing the Generation of Superoxide Anion in Cardiomyocytes. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1046944
American Medical Association (AMA)
Tang, Jing& Hu, Ji-Jie& Lu, Chun-Hua& Liang, Jia-Ni& Xiao, Jin-Fang& Liu, You-Tan…[et al.]. Propofol Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Expression and Myocardial Depression through Decreasing the Generation of Superoxide Anion in Cardiomyocytes. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1046944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046944