The Role of Oxidative Stress and the Effects of Antioxidants on the Incidence of Infectious Complications of Chronic Lymphocytic Leukemia
Joint Authors
Gaman, Amelia Maria
Buga, Ana-Maria
Gaman, Mihnea-Alexandru
Popa-Wagner, Aurel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Chronic lymphocytic leukemia (CLL) is characterized by a predominant humoral immune deficiency predisposing the patients to infections.
Oxidative stress leads to an increased immunoglobulin k light chain production in B cells and contributes to the antibodies’ deficiency and hypogammaglobulinemia.
Aim of the Study.
To evaluate the global oxidative status in patients with CLL and to determine whether the administration of antioxidants decreases complications due to infections.
Patients and Method.
We studied 84 patients with CLL stratified by Binet staging.
Free oxygen radicals and antioxidant status were determined by the FORT and FORD test, respectively, at diagnosis and in the presence of infections.
The patients were distributed in two groups: group A, treated only with antileukemic treatment, and group B, treated with antileukemic treatment and antioxidants.
Results.
By FORD and FORT assay, all patients had at diagnosis a low antioxidant capacity, and high levels of hydroperoxides.
Infectious complications were more frequent in group A (B/C stages of disease) than in group B.
Administrations of antioxidants stimulated the immune response and decreased infectious complications in CLL.
Conclusions.
Administrations of antioxidants and a healthy life style may improve the quality of life of patients with CLL and reduce the risk of infectious complications.
American Psychological Association (APA)
Gaman, Amelia Maria& Buga, Ana-Maria& Gaman, Mihnea-Alexandru& Popa-Wagner, Aurel. 2014. The Role of Oxidative Stress and the Effects of Antioxidants on the Incidence of Infectious Complications of Chronic Lymphocytic Leukemia. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1046949
Modern Language Association (MLA)
Gaman, Amelia Maria…[et al.]. The Role of Oxidative Stress and the Effects of Antioxidants on the Incidence of Infectious Complications of Chronic Lymphocytic Leukemia. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1046949
American Medical Association (AMA)
Gaman, Amelia Maria& Buga, Ana-Maria& Gaman, Mihnea-Alexandru& Popa-Wagner, Aurel. The Role of Oxidative Stress and the Effects of Antioxidants on the Incidence of Infectious Complications of Chronic Lymphocytic Leukemia. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1046949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046949