Catalase Influence in the Regulation of Coronary Resistance by Estrogen: Joint Action of Nitric Oxide and Hydrogen Peroxide
Joint Authors
Belló-Klein, Adriane
Schenkel, Paulo C.
Fernandes, Rafael O.
Viegas, Vinícius U.
Campos, Cristina
Fernandes, Tânia R. G.
Araujo, Alex Sander da Rosa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We tested the influence of estrogen on coronary resistance regulation by modulating nitric oxide (NO) and hydrogen peroxide (H2O2) levels in female rats.
For this, estrogen levels were manipulated and the hearts were immediately excised and perfused at a constant flow using a Langendorff’s apparatus.
Higher estrogen levels were associated with a lower coronary resistance, increased nitric oxide bioavailability, and higher levels of H2O2.
When oxide nitric synthase blockade by L-NAME was performed, no significant changes were found in coronary resistance of ovariectomized rats.
Additionally, we found an inverse association between NO levels and catalase activity.
Taken together, our data suggest that, in the absence of estrogen influence and, therefore, reduced NO bioavailability, coronary resistance regulation seems to be more dependent on the H2O2 that is maintained at low levels by increased catalase activity.
American Psychological Association (APA)
Schenkel, Paulo C.& Fernandes, Rafael O.& Viegas, Vinícius U.& Campos, Cristina& Fernandes, Tânia R. G.& Araujo, Alex Sander da Rosa…[et al.]. 2014. Catalase Influence in the Regulation of Coronary Resistance by Estrogen: Joint Action of Nitric Oxide and Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1046950
Modern Language Association (MLA)
Schenkel, Paulo C.…[et al.]. Catalase Influence in the Regulation of Coronary Resistance by Estrogen: Joint Action of Nitric Oxide and Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-1046950
American Medical Association (AMA)
Schenkel, Paulo C.& Fernandes, Rafael O.& Viegas, Vinícius U.& Campos, Cristina& Fernandes, Tânia R. G.& Araujo, Alex Sander da Rosa…[et al.]. Catalase Influence in the Regulation of Coronary Resistance by Estrogen: Joint Action of Nitric Oxide and Hydrogen Peroxide. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-1046950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046950