Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study
Joint Authors
Arkadopoulos, Nikolaos
Savvanis, Spyridon
Nastos, Constantinos
Tasoulis, Marios-Konstantinos
Papoutsidakis, Nikolaos
Demonakou, Maria
Karmaniolou, Iosifina
Theodoraki, Kassiani
Smyrniotis, Vassilios
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We evaluated the role of sildenafil in a rat liver ischemia-reperfusion model.
Forty male rats were randomly allocated in four groups.
The sham group underwent midline laparotomy only.
In the sildenafil group, sildenafil was administered intraperitoneally 60 minutes before sham laparotomy.
In the ischemia-reperfusion (I/R) group, rats were subjected to 45 minutes of hepatic ischemia followed by 120 minutes of reperfusion, while in the sild+I/R group rats were subjected to a similar pattern of I/R after the administration of sildenafil, 60 minutes before ischemia.
Two hours after reperfusion, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured and histopathological examination of the lobes subjected to ischemia as well as TUNEL staining for apoptotic bodies was performed.
Additionally, myeloperoxidase (MPO) activity and the expression of intercellular adhesion molecule-1 (ICAM-1) were analyzed.
Serum markers of hepatocellular injury were significantly lower in the sild+I/R group, which also exhibited lower severity of histopathological lesions and fewer apoptotic bodies, as compared to the I/R group.
The I/R group showed significantly higher MPO activity and higher expression of ICAM-1, as compared to the sild+I/R group.
Use of sildenafil as a preconditioning agent in a rat model of liver I/R exerted a protective effect.
American Psychological Association (APA)
Savvanis, Spyridon& Nastos, Constantinos& Tasoulis, Marios-Konstantinos& Papoutsidakis, Nikolaos& Demonakou, Maria& Karmaniolou, Iosifina…[et al.]. 2014. Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046951
Modern Language Association (MLA)
Savvanis, Spyridon…[et al.]. Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1046951
American Medical Association (AMA)
Savvanis, Spyridon& Nastos, Constantinos& Tasoulis, Marios-Konstantinos& Papoutsidakis, Nikolaos& Demonakou, Maria& Karmaniolou, Iosifina…[et al.]. Sildenafil Attenuates Hepatocellular Injury after Liver Ischemia Reperfusion in Rats: A Preliminary Study. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1046951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046951