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PELP1 Suppression Inhibits Colorectal Cancer through c-Src Downregulation
Joint Authors
Zhang, Youzhi
Ning, Zhifeng
Chen, Hanwei
Wu, Jiliang
Song, Tieshan
Wu, Qian
Liu, Fuxing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1), a coregulator of estrogen receptors alpha and beta, is a potential protooncogene implicated in several human cancers, including sexual hormone-responsive or sexual hormone-nonresponsive cancers.
However, the functions of PELP1 in colorectal cancer remain unclear.
In this study, western blot and bioinformatics revealed that PELP1 expression was higher in several colorectal cancer cell lines than in immortalized normal colorectal epithelium.
PELP1 silencing by short hairpin RNA promoted the senescence and inhibited the proliferation, colony formation, migration, invasion, and xenograft tumor formation of the CRC cell line HT-29.
Moreover, PELP1 silencing was accompanied by c-Src downregulation.
c-Src upregulation partly alleviated the damage in HT-29 malignant behavior induced by PELP1 RNA interference.
In conclusion, PELP1 exhibits an oncogenic function in colorectal cancer through c-Src upregulation.
American Psychological Association (APA)
Ning, Zhifeng& Zhang, Youzhi& Chen, Hanwei& Wu, Jiliang& Song, Tieshan& Wu, Qian…[et al.]. 2014. PELP1 Suppression Inhibits Colorectal Cancer through c-Src Downregulation. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046956
Modern Language Association (MLA)
Ning, Zhifeng…[et al.]. PELP1 Suppression Inhibits Colorectal Cancer through c-Src Downregulation. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046956
American Medical Association (AMA)
Ning, Zhifeng& Zhang, Youzhi& Chen, Hanwei& Wu, Jiliang& Song, Tieshan& Wu, Qian…[et al.]. PELP1 Suppression Inhibits Colorectal Cancer through c-Src Downregulation. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046956