Withania coagulans Fruit Extract Reduces Oxidative Stress and Inflammation in Kidneys of Streptozotocin-Induced Diabetic Rats
Joint Authors
Adem, Abdu
Ojha, Shreesh
Alkaabi, Juma
Amir, Naheed
Sheikh, Azimullah
Agil, Ahmad
Fahim, Mohamed Abdelmonem
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The present study was carried out to investigate the changes in oxidative and inflammatory status in streptozotocin-induced diabetic rat’s kidneys and serum following treatment with Withania coagulans, a popular herb of ethnomedicinal significance.
The key markers of oxidative stress and inflammation such as inflammatory cytokines (IL-1β, IL-6, and TNF-α) and immunoregulatory cytokines (IL-4 and IFN-γ) were increased in kidneys along with significant hyperglycemia.
However, treatment of four-month diabetic rats with Withania coagulans (10 mg/kg) for 3 weeks significantly attenuated hyperglycemia and reduced the levels of proinflammatory cytokines in kidneys.
In addition, Withania coagulans treatment restored the glutathione levels and inhibited lipid peroxidation along with marked reduction in kidney hypertrophy.
The present study demonstrates that Withania coagulans corrects hyperglycemia and maintained antioxidant status and reduced the proinflammatory markers in kidneys, which may subsequently reduce the development and progression of renal injury in diabetes.
The results of the present study are encouraging for its potential use to delay the onset and progression of diabetic renal complications.
However, the translation of therapeutic efficacy in humans requires further studies.
American Psychological Association (APA)
Ojha, Shreesh& Alkaabi, Juma& Amir, Naheed& Sheikh, Azimullah& Agil, Ahmad& Fahim, Mohamed Abdelmonem…[et al.]. 2014. Withania coagulans Fruit Extract Reduces Oxidative Stress and Inflammation in Kidneys of Streptozotocin-Induced Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046958
Modern Language Association (MLA)
Ojha, Shreesh…[et al.]. Withania coagulans Fruit Extract Reduces Oxidative Stress and Inflammation in Kidneys of Streptozotocin-Induced Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046958
American Medical Association (AMA)
Ojha, Shreesh& Alkaabi, Juma& Amir, Naheed& Sheikh, Azimullah& Agil, Ahmad& Fahim, Mohamed Abdelmonem…[et al.]. Withania coagulans Fruit Extract Reduces Oxidative Stress and Inflammation in Kidneys of Streptozotocin-Induced Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046958