![](/images/graphics-bg.png)
Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis
Joint Authors
Wang, Feng
Zhang, Guangyuan
Zhou, Yang
Gui, Dingkun
Li, Junhui
Xing, Tao
Wang, Niansong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Magnolin is the major active ingredient of the herb Magnolia fargesii which has anti-inflammatory and antioxidative effects.
Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN).
We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties.
Methods.
To test whether Magnolin could attenuate CIN, oxidative stress and apoptosis, in vivo and in vitro, we utilized a rat model of ioversol-induced CIN and a cell model of oxidative stress in which HK2 cells were treated with H2O2.
Rats were assigned to 4 groups (n=6 per group): control group, ioversol group (ioversol-induced CIN), vehicle group (CIN rats pretreated with vehicle), and Magnolin group (CIN rats pretreated with 1 mg/kg Magnolin).
Results.
The results showed that magnolin ameliorated the renal tubular necrosis, apoptosis, and the deterioration of renal function (P<0.05).
Furthermore, Magnolin reduced the renal oxidative stress, suppressed caspase-3 activity, and increased Bcl-2 expression in vivo and in vitro.
Conclusion.
Magnolin might protect CIN in rats through antioxidation and antiapoptosis.
American Psychological Association (APA)
Wang, Feng& Zhang, Guangyuan& Zhou, Yang& Gui, Dingkun& Li, Junhui& Xing, Tao…[et al.]. 2014. Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046959
Modern Language Association (MLA)
Wang, Feng…[et al.]. Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1046959
American Medical Association (AMA)
Wang, Feng& Zhang, Guangyuan& Zhou, Yang& Gui, Dingkun& Li, Junhui& Xing, Tao…[et al.]. Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1046959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046959