L-ArginineNO Pathway Is Altered in Children with Haemolytic-Uraemic Syndrome (HUS)
Joint Authors
Vaske, Bernhard
Kanzelmeyer, Nele Kirsten
Pape, Lars
Chobanyan-Jürgens, Kristine
Tsikas, Dimitrios
Hartmann, Hans
Fuchs, Anne-Jule
Haubitz, Marion
Jordan, Jens
Lücke, Thomas
Das, Anibh M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The haemolytic uraemic syndrome (HUS) is the most frequent cause of acute renal failure in childhood.
We investigated L-arginine/NO pathway in 12 children with typical HUS and 12 age-matched healthy control subjects.
Nitrite and nitrate, the major NO metabolites in plasma and urine, asymmetric dimethylarginine (ADMA) in plasma and urine, and dimethylamine (DMA) in urine were determined by GC-MS and GC-MS/MS techniques.
Urinary measurements were corrected for creatinine excretion.
Plasma nitrate was significantly higher in HUS patients compared to healthy controls P = 0.021 , whereas urine nitrate was borderline lower in HUS patients compared to healthy controls P = 0.24 .
ADMA plasma concentrations were insignificantly lower, but urine ADMA levels were significantly lower in the HUS patients P = 0.019 .
Urinary DMA was not significantly elevated.
In HUS patients, nitrate R = 0.91 but not nitrite, L-arginine, or ADMA concentrations in plasma correlated with free haemoglobin concentration.
Our results suggest that both NO production and ADMA synthesis are decreased in children with typical HUS.
We hypothesize that in the circulation of children with HUS a vicious circle between the L-arginine/NO pathway and free haemoglobin-mediated oxidative stress exists.
Disruption of this vicious circle by drugs that release NO and/or sulphydryl groups-containing drugs may offer new therapeutic options in HUS.
American Psychological Association (APA)
Kanzelmeyer, Nele Kirsten& Pape, Lars& Chobanyan-Jürgens, Kristine& Tsikas, Dimitrios& Hartmann, Hans& Fuchs, Anne-Jule…[et al.]. 2014. L-ArginineNO Pathway Is Altered in Children with Haemolytic-Uraemic Syndrome (HUS). Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046960
Modern Language Association (MLA)
Kanzelmeyer, Nele Kirsten…[et al.]. L-ArginineNO Pathway Is Altered in Children with Haemolytic-Uraemic Syndrome (HUS). Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1046960
American Medical Association (AMA)
Kanzelmeyer, Nele Kirsten& Pape, Lars& Chobanyan-Jürgens, Kristine& Tsikas, Dimitrios& Hartmann, Hans& Fuchs, Anne-Jule…[et al.]. L-ArginineNO Pathway Is Altered in Children with Haemolytic-Uraemic Syndrome (HUS). Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1046960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1046960